Description
What It Is
Serelose contains lactulose (3.35 g per 5 ml), a non-absorbable osmotic laxative that helps soften stools by drawing water into the colon. It’s commonly used for:
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Chronic constipation
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Management of hepatic encephalopathy by reducing blood ammonia levels
How It Works
Lactulose undergoes fermentation in the colon, producing organic acids (like lactic acid) that:
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Increase osmotic pressure, drawing water into the bowel (softens stool, stimulates peristalsis)
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Acidify the colon contents, converting ammonia (NH₃) to ammonium (NH₄⁺)—reducing its absorption and alleviating hepatic encephalopathy symptoms
Indications & Uses
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Constipation (Adults): Start with 15–30 ml once daily, increasing to up to 60 ml if needed.
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Hepatic Encephalopathy (Prophylaxis): 30–45 ml every 6–8 hours, adjusted to achieve 2–3 soft stools per day.
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Acute Cases: Up to 30–45 ml hourly until soft stool achieved, then maintenance dosing.
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Children: 1–3 ml/kg/day (max 60 ml/day), adjusted for stool frequency.
Safety & Side Effects
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Common: Bloating, flatulence, abdominal cramps (usually mild and temporary)
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Overdose: Diarrhea, dehydration, and electrolyte disturbances (especially low potassium)
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Contraindications: Galactosemia, intestinal obstruction
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Precautions: Use cautiously in lactose intolerance or diabetic patients; dose may require adjustment
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Generally safe during pregnancy (Category B) and breastfeeding, but follow medical advice
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